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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Bergamottin, Simvastatin
Phytochemical Name Bergamottin (PubChem CID: 5471349 )
Anticancer drug Name Simvastatin (PubChem CID: 54454 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 332
Ref_1
Pair Name Bergamottin, Simvastatin
Disease Info [ICD-11: 2A20.1] Chronic myelogenous leukemia Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BCL-xL hsa598
Down-regulation Expression BIRC2 hsa329
Down-regulation Expression BIRC5 hsa332
Down-regulation Expression CCND1 hsa595
Up-regulation Expression CDKN1A hsa1026
Down-regulation Expression MMP9 hsa4318
Down-regulation Expression NFKB1 hsa4790
Up-regulation Expression NFKBIA hsa4792
Up-regulation Expression PSMD9 hsa5715
Up-regulation Expression RELA hsa5970
Down-regulation Expression VEGFA hsa7422
In Vitro Model KBM-5 Chronic myelogenous leukemia Homo sapiens (Human) CVCL_0373
AIP WT MEF Healthy Mus musculus (Mouse) CVCL_UJ03
Result Discussion and conclusion Our results provide novel insight into the role of SV and BGM in potentially preventing and treating cancer through modulation of NF-κB signalling pathway and its regulated gene products.
03. Reference
No. Title Href
1 Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia. Pharm Biol. 2016 Oct;54(10):2050-60. doi: 10.3109/13880209.2016.1141221. Click
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